Diagnosis

• Characterisation of solitary pulmonary nodules
• Detection of cancer of unknown origin, revealed for example by cervical adenopathy, liver or bones metastases
• Characterisation of a pancreatic mass

Staging

• Head and neck cancers including assistance in guiding biopsy
• Primary lung cancer
• Locally advanced breast cancer
• Oesophageal cancer
• Carcinoma of the pancreas
• Colorectal cancer particularly in restaging recurrences
• Malignant lymphoma
• Malignant melanoma, Breslow > 1.5 mm or lymph node metastasis at first diagnosis

Monitoring of therapeutic Response:

• Malignant lymphoma
• Head and neck cancers

Detection in case of reasonable suspicion of recurrences:

• Glioma with high grade of malignancy (III or IV)
• Head and neck cancers
• Thyroid cancer (non-medullary): patients with increased thyroglobulin serum levels and negative radioactive iodine whole body scintigraphy
• Primary lung cancer
• Breast cancer
• Carcinoma of the pancreas
• Colorectal cancer
• Ovarian cancer
• Malignant lymphoma
• Malignant melanoma

Cardiology

In the cardiologic indication, the diagnostic target is viable myocardial tissue that takes-up glucose but is hypo-perfused, as it must be assessed beforehand using appropriate blood-flow imaging techniques.

• • Evaluation of myocardial viability in patients with severe impaired left ventricular function who are candidates for revascularisation when conventional imaging modalities are not contributive.

In the neurologic indication the interictal glucose hypometabolism is the diagnostic target:

• • Localisation of epileptogenic foci in the presurgical evaluation of partial temporal epilepsy.

Infectious or inflammatory diseases

In infectious or inflammatory diseases, the diagnostic target is tissue or structures with an abnormal content of activated white blood cells. In infectious or inflammatory diseases, the following indications are sufficiently documented: Localisation of abnormal foci guiding the aetiologic diagnosis in case of fever of unknown origin

Diagnosis of infection in case of:

• Suspected chronic infection of bone and/or adjacent structures: osteomyelitis, spondilitis, diskitis or osteitis including when metallic implants are present
• Diabetic patient with a foot suspicious of Charcot’s neuroarthropathy, osteomyelitis and/or soft tissue infection
• Painful hip prosthesis
• Vascular prosthesis
• Fever in an AIDS Patient
• Detection of septic metastatic foci in case of bacteraemia or endocarditis (see also section 4.4)

Detection of the extension of inflammation in case of:

• Sarcoidosis
• Inflammatory bowel disease
• Vasculitis involving the great vessels

Therapy follow-up

Unresectable alveolar echinococcosis, in search for active localisations of the parasite during medical treatment and after treatment discontinuation.